Enhanced efficacy of CBT following augmentation with amygdala rtfMRI neurofeedback in depression.

ABSTRACT:

Background

Despite cognitive behavioral therapy (CBT) being a standard treatment in major depressive disorder (MDD), nearly half of patients do not respond. As one of the predictors of CBT's efficacy is amygdala reactivity to positive information, which is often decreased in MDD, we explored whether real-time fMRI neurofeedback (rtfMRI-nf) training to increase amygdala responses during positive memory recall prior CBT would enhance its efficacy.

Methods

In a double-blind, placebo controlled, randomized clinical trial, 35 adults with MDD received two sessions of rtfMRI-nf training to increase their amygdala (experimental group, n = 16) or parietal (control group, n = 19) responses during positive memory neurofeedback prior to receiving 10 CBT sessions. Depressive symptomatolo

SUBMITTER: Compere L 

PROVIDER: S-EPMC10530481 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature