Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks.

ABSTRACT:

Background

Brain-based interventions are needed to address persistent relapse in alcohol use disorder (AUD). Neuroimaging evidence suggests higher frontal connectivity as well as higher within-network connectivity of theoretically defined addiction networks are associated with reduced relapse rates and extended abstinence during follow-up periods.

Objective

/Hypothesis: A longitudinal randomized double-blind sham-controlled clinical trial investigated whether a non-invasive neuromodulation intervention delivered during early abstinence can (i) modulate connectivity of addiction networks supporting abstinence and (ii) improve relapse rates.

Hypotheses

Active transcranial direct current stimulation (tDCS) will (i) increase connectivity of addiction networks known to sup

SUBMITTER: Camchong J 

PROVIDER: S-EPMC10530485 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature