Investigating Neuron Degeneration in Huntington's Disease Using RNA-Seq Based Transcriptome Study.

ABSTRACT: Huntington's disease (HD) is a progressive neurodegenerative disorder caused due to a CAG repeat expansion in the huntingtin (HTT) gene. The primary symptoms of HD include motor dysfunction such as chorea, dystonia, and involuntary movements. The primary motor cortex (BA4) is the key brain region responsible for executing motor/movement activities. Investigating patient and control samples from the BA4 region will provide a deeper understanding of the genes responsible for neuron degeneration and help to identify potential markers. Previous studies have focused on overall differential gene expression and associated biological functions. In this study, we illustrate the relationship between variants and differentially expressed genes/transcripts. We identified variants and their asso

SUBMITTER: Sneha NP 

PROVIDER: S-EPMC10530489 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature