Differences in patient-reported outcomes (PROs) by disease severity in light chain (AL) amyloidosis.

ABSTRACT:

Objective

To assess the impact of organ involvement on patient-reported outcomes (PROs) in light chain (AL) amyloidosis.

Methods

PROs were evaluated using the KCCQ-12, PROMIS-29 + 2, and SF-36 in individuals with AL amyloidosis. The 2004 Mayo system was used to stage disease and cardiac, neurologic, and renal involvement was considered. Global physical and mental health (MH) scores, physical function (PF), fatigue, social function (SF), pain, sleep, and MH domains were evaluated. Effect sizes between scores were measured using Cohen's d.

Results

Of 297 respondents, the median age at diagnosis was 60 years with 58% cardiac, 58% renal, and 30% neurologic involvement. Fatigue, PF, SF, and global physical health with PROMIS and SF-36 discriminated the most by stage. Signi

SUBMITTER: D'Souza A 

PROVIDER: S-EPMC10530507 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature