Ghrelin's orexigenic action in the lateral hypothalamic area involves indirect recruitment of orexin neurons and arcuate nucleus activation.

ABSTRACT:

Objective

Ghrelin is a potent orexigenic hormone, and the lateral hypothalamic area (LHA) has been suggested as a putative target mediating ghrelin's effects on food intake. Here, we aimed to investigate the presence of neurons expressing ghrelin receptor (a.k.a. growth hormone secretagogue receptor, GHSR) in the mouse LHA (LHA^GHSR neurons), its physiological implications and the neuronal circuit recruited by local ghrelin action.

Methods

We investigated the distribution of LHA^GHSR neurons using different histologic strategies, including the use of a reporter mice expressing enhanced green fluorescent protein under the control of the GHSR promoter. Also, we investigated the physiological implications of local injections of ghrelin within the LHA, and th

SUBMITTER: Barrile F 

PROVIDER: S-EPMC10530520 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature