An RFX transcription factor regulates ciliogenesis in the closest living relatives of animals.

ABSTRACT: Cilia allowed our protistan ancestors to sense and explore their environment, avoid predation, and capture bacterial prey.^1,2,3 Regulated ciliogenesis was likely critical for early animal evolution,^2,4,5,6 and in modern animals, deploying cilia in the right cells at the right time is crucial for development and physiology. Two transcription factors, RFX and FoxJ1, coordinate ciliogenesis in animals^7,8,9 but are absent from the genomes of many other ciliated eukaryotes, raising the question of how the regulation of ciliogenesis in animals evolved.^10,11 By comparing the genom

SUBMITTER: Coyle MC 

PROVIDER: S-EPMC10530576 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature