Positive Allosteric Modulators of SERCA Pump Restore Dendritic Spines and Rescue Long-Term Potentiation Defects in Alzheimer's Disease Mouse Model.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder that affects memory formation and storage processes. Dysregulated neuronal calcium (Ca²⁺) has been identified as one of the key pathogenic events in AD, and it has been suggested that pharmacological agents that stabilize Ca²⁺ neuronal signaling can act as disease-modifying agents in AD. In previous studies, we demonstrated that positive allosteric regulators (PAMs) of the sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) pump might act as such Ca²⁺-stabilizing agents and exhibit neuroprotective properties. In the present study, we evaluated effects of a set of novel SERCA PAM agents on the rate of Ca²⁺ extraction from the cytoplasm of the HEK293T cell line, on morphometric paramet

SUBMITTER: Rakovskaya A 

PROVIDER: S-EPMC10530588 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature