Iron promotes glycolysis to drive colon tumorigenesis.

ABSTRACT: Colorectal cancer (CRC) is the third most common cancer and is also the third leading cause of cancer-related death in the USA. Understanding the mechanisms of growth and progression of CRC is essential to improve treatment. Macronutrients such as glucose are energy source for a cell. Many tumor cells exhibit increased aerobic glycolysis. Increased tissue micronutrient iron levels in both mice and humans are also associated with increased colon tumorigenesis. However, if iron drives colon carcinogenesis via affecting glucose metabolism is still not clear. Here we found the intracellular glucose levels in tumor colonoids were significantly increased after iron treatment. ¹³C-labeled glucose flux analysis indicated that the levels of several labeled glycolytic products were signif

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10530594 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature