Design and analysis of partially randomized preference trials with propensity score stratification.

ABSTRACT: While the two-stage randomized design allows us to unbiasedly evaluate the impact of patients' treatment preference on the outcome of interest, it may not always be practical to implement in clinical practice; patients with a strong preference may not be willing to be randomized. The more pragmatic, partially randomized preference design (PRPD) allows patients who are unwilling to be randomized, but willing to state their preference, to receive their preferred treatment in lieu of the first-stage randomization in the two-stage design, at the cost of potentially introducing bias in estimating the effects of interest. In this article, we consider the application of propensity score stratification (PSS) in a PRPD to recreate a conditional first-stage randomization based on observed covariates

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10530658 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature