Diprosopus: A Rare Case of Craniofacial Duplication and a Systematic Review of the Literature.

ABSTRACT: In 1990, Gorlin et al. described four types of craniofacial duplications: (1) single mouth with duplication of the maxillary arch; (2) supernumerary mouth laterally placed with rudimentary segments; (3) single mouth with replication of the mandibular segments; and (4) true facial duplication, namely diprosopus. We describe a newborn born with wide-spaced eyes, a very broad nose, and two separate mouths. Workup revealed the absence of the corpus callosum and the presence of a brain midline lipoma, wide sutures, and a Chiari I malformation with cerebellar herniation. We conducted a systematic review of the literature and compared all the cases described as diprosopus. In 96% of these, the central nervous system is affected, with anencephaly being the most commonly associated abnormality. Oth

SUBMITTER: Trevisani V 

PROVIDER: S-EPMC10530716 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature