For Someone, You Are the Whole World: Host-Specificity of Salmonella enterica.

ABSTRACT: Salmonella enterica is a bacterial pathogen known to cause gastrointestinal infections in diverse hosts, including humans and animals. Despite extensive knowledge of virulence mechanisms, understanding the factors driving host specificity remains limited. In this study, we performed a comprehensive pangenome-wide analysis of S. enterica to identify potential loci determining preference towards certain hosts. We used a dataset of high-quality genome assemblies grouped into 300 reference clusters with a special focus on four host groups: humans, pigs, cattle, and birds. The reconstructed pangenome was shown to be open and enriched with the accessory component implying high genetic diversity. Notably, phylogenetic inferences did not correspond to the distribution of affected hos

SUBMITTER: Merkushova AV 

PROVIDER: S-EPMC10530738 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature