Mitigation of Dextran-Sodium-Sulfate-Induced Colitis in Mice through Oral Administration of Microbiome-Derived Inosine and Its Underlying Mechanisms.

ABSTRACT:

Background

Colonic and serum inosine are significantly reduced in patients with inflammatory bowel disease (IBD).

Methods

This study aimed to explore whether microbiome-derived inosine alleviates colitis and its underlying mechanisms.

Results

An inosine intervention effectively improved the clinical signs in colitis mice, suppressed inflammatory cytokines (tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and IL-1β) by regulating the nuclear factor-kappa B (NF-κB) pathway, and elevated the activities of anti-oxidative enzymes (including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)) by regulating the nuclear factor erythroid-2 related factor 2 (Nrf2) pathway. Additionally, the inosine intervention significantly elevated the expression of tigh

SUBMITTER: Guo W 

PROVIDER: S-EPMC10530753 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature