Remote Positioning of Spherical Alginate Ferrogels in a Fluid Flow by a Magnetic Field: Experimental and Computer Simulation.

ABSTRACT: This work belongs to the development of mechanical force-responsive drug delivery systems based on remote stimulation by an external magnetic field at the first stage, assisting the positioning of a ferrogel-based targeted delivery platform in a fluid flow. Magnetically active biopolymer beads were considered a prototype implant for the needs of replacement therapy and regenerative medicine. Spherical calcium alginate ferrogels (FGs)~2.4 mm in diameter, filled with a 12.6% weight fraction of magnetite particles of 200-300 nm in diameter, were synthesized. A detailed characterization of the physicochemical and magnetic properties of FGs was carried out, as were direct measurements of the field dependence of the attractive force for FG-beads. The hydrodynamic effects of the positioning of FG

SUBMITTER: Blyakhman F 

PROVIDER: S-EPMC10530833 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature