Identification and Analysis of Sex-Biased MicroRNAs in Human Diseases.

ABSTRACT: It is well known that significant differences exist between males and females in both physiology and disease. Thus, it is important to identify and analyze sex-biased miRNAs. However, previous studies investigating sex differences in miRNA expression have predominantly focused on healthy individuals or restricted their analysis to a single disease. Therefore, it is necessary to comprehensively identify and analyze the sex-biased miRNAs in diseases. For this purpose, in this study, we first identified the miRNAs showing sex-biased expression between males and females in diseases based on a number of miRNA expression datasets. Then, we performed a bioinformatics analysis for these sex-biased miRNAs. Notably, our findings revealed that women exhibit a greater number of conserved miRNAs that a

SUBMITTER: Zhong B 

PROVIDER: S-EPMC10531062 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature