Phenotyping left ventricular systolic dysfunction in asymptomatic individuals for improved risk stratification.

ABSTRACT:

Aims

Left ventricular systolic dysfunction (LSVD) is a heterogeneous condition with several factors influencing prognosis. Better phenotyping of asymptomatic individuals can inform preventative strategies. This study aims to explore the clinical phenotypes of LVSD in initially asymptomatic subjects and their association with clinical outcomes and cardiovascular abnormalities through multi-dimensional data clustering.

Methods and results

Clustering analysis was performed on 60 clinically available variables from 1563 UK Biobank participants without pre-existing heart failure (HF) and with left ventricular ejection fraction (LVEF) < 50% on cardiovascular magnetic resonance (CMR) assessment. Risks of developing HF, other cardiovascular events, death, and a composite of major ad

SUBMITTER: Rauseo E 

PROVIDER: S-EPMC10531121 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature