Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse.

ABSTRACT: Mitochondrial dysfunction is strongly associated with autism spectrum disorder (ASD) and the Inner mitochondrial membrane protein 2-like (IMMP2L) gene is linked to autism inheritance. However, the biological basis of this linkage is unknown notwithstanding independent reports of oxidative stress in association with both IMMP2L and ASD. To better understand IMMP2L's association with behaviour, we developed the Immp2l^KD knockout (KO) mouse model which is devoid of Immp2l peptidase activity. Immp2l^KD -/- KO mice do not display any of the core behavioural symptoms of ASD, albeit homozygous Immp2l^KD -/- KO mice do display increased auditory stimulus-driven instrumental behaviour and increased amphetamine-induced locomotion. Due

SUBMITTER: Lawther AJ 

PROVIDER: S-EPMC10531238 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature