Aldehyde Dehydrogenase Genes as Prospective Actionable Targets in Acute Myeloid Leukemia.

ABSTRACT: It has been previously shown that the aldehyde dehydrogenase (ALDH) family member ALDH1A1 has a significant association with acute myeloid leukemia (AML) patient risk group classification and that AML cells lacking ALDH1A1 expression can be readily killed via chemotherapy. In the past, however, a redundancy between the activities of subgroup members of the ALDH family has hampered the search for conclusive evidence to address the role of specific ALDH genes. Here, we describe the bioinformatics evaluation of all nineteen member genes of the ALDH family as prospective actionable targets for the development of methods aimed to improve AML treatment. We implicate ALDH1A1 in the development of recurrent AML, and we show that from the nineteen members o

SUBMITTER: Dancik GM 

PROVIDER: S-EPMC10531322 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature