Transcriptome Signature of Immature and In Vitro-Matured Equine Cumulus-Oocytes Complex.

ABSTRACT: Maturation is a critical step in the development of an oocyte, and it is during this time that the oocyte advances to metaphase II (MII) of the meiotic cycle and acquires developmental competence to be fertilized and become an embryo. However, in vitro maturation (IVM) remains one of the limiting steps in the in vitro production of embryos (IVP), with a variable percentage of oocytes reaching the MII stage and unpredictable levels of developmental competence. Understanding the dynamics of oocyte maturation is essential for the optimization of IVM culture conditions and subsequent IVP outcomes. Thus, the aim of this study was to elucidate the transcriptome dynamics of oocyte maturation by comparing transcriptomic changes during in vitro maturation in both oocytes and their surrounding cumul

SUBMITTER: de la Fuente A 

PROVIDER: S-EPMC10531358 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature