One Step Closer to the Understanding of the Relationship IDR-LCR-Structure.

ABSTRACT: Intrinsically disordered regions (IDRs) in protein sequences are emerging as functionally important elements for interaction and regulation. While being generally flexible, we previously showed, by observation of experimentally obtained structures, that they contain regions of reduced sequence complexity that have an increased propensity to form structure. Here we expand the universe of cases taking advantage of structural predictions by AlphaFold. Our studies focus on low complexity regions (LCRs) found within IDRs, where these LCRs have only one or two residue types (polyX and polyXY, respectively). In addition to confirming previous observations that polyE and polyEK have a tendency towards helical structure, we find a similar tendency for other LCRs such as polyQ and polyER, most of th

SUBMITTER: Goncalves-Kulik M 

PROVIDER: S-EPMC10531472 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature