T-Cadherin Deficiency Is Associated with Increased Blood Pressure after Physical Activity.

ABSTRACT: T-cadherin is a regulator of blood vessel remodeling and angiogenesis, involved in adiponectin-mediated protective effects in the cardiovascular system and in skeletal muscles. GWAS study has previously demonstrated a SNP in the Cdh13 gene to be associated with hypertension. However, the role of T-cadherin in regulating blood pressure has not been experimentally elucidated. Herein, we generated Cdh13^∆Exon3 mice lacking exon 3 in the Cdh13 gene and described their phenotype. Cdh13^∆Exon3 mice exhibited normal gross morphology, life expectancy, and breeding capacity. Meanwhile, their body weight was considerably lower than of WT mice. When running on a treadmill, the time spent running and the distance covered by Cdh13^∆Exon3 mice was similar to t

SUBMITTER: Popov VS 

PROVIDER: S-EPMC10531645 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature