Antifungal Efficacy of Antimicrobial Peptide Octominin II against Candida albicans.

ABSTRACT: Most clinically isolated Candida albicans strains are drug-resistant, emphasizing the urgent need to discover alternative therapies. In this study, the previously characterized Octominin was modified into a shorter peptide with an 18 amino acid sequence (¹GWLIRGAIHAGKAIHGLI¹⁸) and named Octominin II. The secondary structure of Octominin II is a random coil with a helical turn and a positive charge (+2.46) with a hydrophobic ratio of 0.46. Octominin II inhibited C. albicans, C. auris, and C. glabrata with minimum inhibitory and fungicidal concentrations against C. albicans of 80 and 120 µg/mL, respectively. Field emission scanning electron microscopy confirmed that Octominin II treatment caused ultra-structural changes in C. albica

SUBMITTER: Jayasinghe JNC 

PROVIDER: S-EPMC10531694 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature