Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences.

ABSTRACT: Extra- and intra-cellular activity occurs under the direction of numerous inter-molecular interactions, and in any tissue or cell, molecules are densely packed, thus promoting those molecular interactions. Galectins and chemokines, the focus of this review, are small, protein effector molecules that mediate various cellular functions-in particular, cell adhesion and migration-as well as cell signaling/activation. In the past, researchers have reported that combinations of these (and other) effector molecules act separately, yet sometimes in concert, but nevertheless physically apart and via their individual cell receptors. This view that each effector molecule functions independently of the other limits our thinking about functional versatility and cooperation, and, in turn, ignores the pr

SUBMITTER: Mayo KH 

PROVIDER: S-EPMC10531749 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature