Carboxymethyl Chitosan Hydrogels for Effective Wound Healing-An Animal Study.

ABSTRACT: Hydrogels have various applications in medicine, for example, in systems for controlled drug release or as wound dressings, where they provide an appropriate environment for healing and constitute a barrier to microorganisms. The aim of this study was to evaluate the action of carboxymethyl chitosan (CMCS) hydrogels in wound healing therapy in vivo using a laboratory rat model. The hydrogels were formed from aqueous solutions of a CMCS biopolymer via electron beam irradiation, with the presence of a crosslinking agent of poly(ethylene glycol) diacrylate. A histopathological examination of injured tissue, using a model of a hard-to-heal wound, indicated that the CMCS hydrogel supported healing. The new gel dressing, being noncytotoxic, presents great potential in wound treatment, with posit

SUBMITTER: Klosinski KK 

PROVIDER: S-EPMC10531907 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature