Short Survey on the Protein Modifications in Plasma during SARS-CoV-2 Infection.

ABSTRACT: Although the COVID-19 pandemic has ended, it is important to understand the pathology of severe SARS-CoV-2 infection associated with respiratory failure and high mortality. The plasma proteome, including protein modification by lipid peroxidation products in COVID-19 survivors (COVID-19; n = 10) and deceased individuals (CovDeath; n = 10) was compared in samples collected upon admission to the hospital, when there was no difference in their status, with that of healthy individuals (Ctr; n = 10). The obtained results show that COVID-19 development strongly alters the expression of proteins involved in the regulation of exocytosis and platelet degranulation (top 20 altered proteins indicated by analysis of variance; p-value (False Discovery Rate) cutoff at 5%). Th

SUBMITTER: Gegotek A 

PROVIDER: S-EPMC10531908 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature