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Emerging Roles of Using Small Extracellular Vesicles as an Anti-Cancer Drug.

ABSTRACT: Small extracellular vesicles (sEVs) are emerging as a novel therapeutic strategy for cancer therapy. Tumor-cell-derived sEVs contain biomolecules that can be utilized for cancer diagnosis. sEVs can directly exert tumor-killing effects or modulate the tumor microenvironment, leading to anti-cancer effects. In this review, the application of sEVs as a diagnostic tool, drug delivery system, and active pharmaceutical ingredient for cancer therapy will be highlighted. The therapeutic efficacies of sEVs will be compared to conventional immune checkpoint inhibitors. Additionally, this review will provide strategies for sEV engineering to enhance the therapeutic efficacies of sEVs. As a bench-to-bedside application, we will discuss approaches to encourage good-manufacturing-practice-compliant industrial-scale manufacturing and purification of sEVs.

SUBMITTER: Joo HS

PROVIDER: S-EPMC10531913 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Emerging Roles of Using Small Extracellular Vesicles as an Anti-Cancer Drug.

Joo Hyeon Su HS Suh Ju Hun JH So Chan Mi CM Jeon Hye Jin HJ Yoon Sol Hee SH Lee Jung Min JM

International journal of molecular sciences 20230914 18

Small extracellular vesicles (sEVs) are emerging as a novel therapeutic strategy for cancer therapy. Tumor-cell-derived sEVs contain biomolecules that can be utilized for cancer diagnosis. sEVs can directly exert tumor-killing effects or modulate the tumor microenvironment, leading to anti-cancer effects. In this review, the application of sEVs as a diagnostic tool, drug delivery system, and active pharmaceutical ingredient for cancer therapy will be highlighted. The therapeutic efficacies of sE ...[more]

PMID: 37762393

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