The Impact of Intestinal Inflammation on Nematode's Excretory-Secretory Proteome.

ABSTRACT: Parasitic nematodes and their products are promising candidates for therapeutics against inflammatory bowel diseases (IBD). Two species of nematodes, the hookworm Necator americanus and the whipworm Trichuis suis, are being used in clinical treatment trials of IBD referred to as "helminth therapy". Heligmosomoides polygyrus is a well-known model for human hookworm infections. Excretory-secretory (ES) products of H. polygyrus L4 stage that developed during colitis show a different immunomodulatory effect compared to the ES of H. polgyrus from healthy mice. The aim of the study was to evaluate excretory-secretory proteins produced by H. polygyrus L4 stage males and females that developed in the colitic milieu. Mass spectrometry was used to identify p

SUBMITTER: Maruszewska-Cheruiyot M 

PROVIDER: S-EPMC10531923 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature