Alkylresorcinols as New Modulators of the Metabolic Activity of the Gut Microbiota.

ABSTRACT: Alkylresorcinols (ARs) are polyphenolic compounds with a wide spectrum of biological activities and are potentially involved in the regulation of host metabolism. The present study aims to establish whether ARs can be produced by the human gut microbiota and to evaluate alterations in content in stool samples as well as metabolic activity of the gut microbiota of C57BL, db/db, and LDLR (-/-) mice according to diet specifications and olivetol (5-n-pentylresorcinol) supplementation to estimate the regulatory potential of ARs. Gas chromatography with mass spectrometric detection was used to quantitatively analyse AR levels in mouse stool samples; faecal microbiota transplantation (FMT) from human donors to germ-free mice was performed to determine whether the intestinal microbiota coul

SUBMITTER: Zabolotneva AA 

PROVIDER: S-EPMC10532030 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature