A Comparative Study of HA/DBM Compounds Derived from Bovine and Porcine for Bone Regeneration.

ABSTRACT: This comparative study investigated the tissue regeneration and inflammatory response induced by xenografts comprised of hydroxyapatite (HA) and demineralized bone matrix (DBM) extracted from porcine (P) and bovine (B) sources. First, extraction of HA and DBM was independently conducted, followed by chemical and morphological characterization. Second, mixtures of HA/DBM were prepared in 50/50 and 60/40 concentrations, and the chemical, morphological, and mechanical properties were evaluated. A rat calvarial defect model was used to evaluate the tissue regeneration and inflammatory responses at 3 and 6 months. The commercial allograft DBM Puros^® was used as a clinical reference. Different variables related to tissue regeneration were evaluated, including tissue thickness regenera

SUBMITTER: Roldan L 

PROVIDER: S-EPMC10532284 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature