Global Gene Expression of Post-Senescent Telomerase-Negative ter1Δ Strain of Ustilago maydis.

ABSTRACT: We analyzed the global expression patterns of telomerase-negative mutants from haploid cells of Ustilago maydis to identify the gene network required for cell survival in the absence of telomerase. Mutations in either of the telomerase core subunits (trt1 and ter1) of the dimorphic fungus U. maydis cause deficiencies in teliospore formation. We report the global transcriptome analysis of two ter1Δ survivor strains of U. maydis, revealing the deregulation of telomerase-deleted responses (TDR) genes, such as DNA-damage response, stress response, cell cycle, subtelomeric, and proximal telomere genes. Other differentially expressed genes (DEGs) found in the ter1Δ survivor strains were related to pathogenic lifestyle factors, plant-pathogen cross

SUBMITTER: Sanpedro-Luna JA 

PROVIDER: S-EPMC10532341 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature