Understanding Glioblastoma Signaling, Heterogeneity, Invasiveness, and Drug Delivery Barriers.

ABSTRACT: The most prevalent and aggressive type of brain cancer, namely, glioblastoma (GBM), is characterized by intra- and inter-tumor heterogeneity and strong spreading capacity, which makes treatment ineffective. A true therapeutic answer is still in its infancy despite various studies that have made significant progress toward understanding the mechanisms behind GBM recurrence and its resistance. The primary causes of GBM recurrence are attributed to the heterogeneity and diffusive nature; therefore, monitoring the tumor's heterogeneity and spreading may offer a set of therapeutic targets that could improve the clinical management of GBM and prevent tumor relapse. Additionally, the blood-brain barrier (BBB)-related poor drug delivery that prevents effective drug concentrations within the tumor

SUBMITTER: Rabah N 

PROVIDER: S-EPMC10532387 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature