Radical Hysterectomy in Early-Stage Cervical Cancer: Abandoning the One-Fits-All Concept.

ABSTRACT: Two pillars in modern oncology are treatment personalization and the reduction in treatment-related morbidity. For decades, the one-fits-all concept of radical hysterectomy has been the cornerstone of early-stage cervical cancer surgical treatment. However, no agreement exists about the prevalent method of parametrial invasion, and the literature is conflicting regarding the extent of parametrectomy needed to achieve adequate surgical radicality. Therefore, authors started investigating if less radical surgery was feasible and oncologically safe in these patients. Two historical randomized controlled trials (RCTs) compared classical radical hysterectomy (RH) to modified RH and simple hysterectomy. Less radical surgery showed a drastic reduction in morbidity without jeopardizing oncological

SUBMITTER: Bianchi T 

PROVIDER: S-EPMC10532817 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature