MicroRNA as a Maternal Marker for Prenatal Stress-Associated ASD, Evidence from a Murine Model.

ABSTRACT: Autism Spectrum Disorder (ASD) has been associated with a complex interplay between genetic and environmental factors. Prenatal stress exposure has been identified as a possible risk factor, although most stress-exposed pregnancies do not result in ASD. The serotonin transporter (SERT) gene has been linked to stress reactivity, and the presence of the SERT short (S)-allele has been shown to mediate the association between maternal stress exposure and ASD. In a mouse model, we investigated the effects of prenatal stress exposure and maternal SERT genotype on offspring behavior and explored its association with maternal microRNA (miRNA) expression during pregnancy. Pregnant female mice were divided into four groups based on genotype (wildtype or SERT heterozygous knockout (Sert-het)) and the

SUBMITTER: Woo T 

PROVIDER: S-EPMC10533003 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature