Inflammatory macrophages exploited by oral streptococcus increase IL-1B release via NLRP6 inflammasome.

ABSTRACT: Chronic inflammatory periodontal disease develops in part from the infiltration of a large number of classically activated inflammatory macrophages that release inflammatory cytokines important for disease progression, including inflammasome-dependent interleukin (IL)-1β. Streptococcus gordonii is a normally commensal oral microorganism; while not causative, recent evidence indicates that commensal oral microbes are required for the full development of periodontal disease. We have recently reported that inflammatory macrophages counterintuitively allow for the increased survival of phagocytosed S. gordonii over nonactivated or alternatively activated macrophages. This survival is dependent on increased reactive oxygen species production within the phagosome of the inflammatory macrophages,

SUBMITTER: Metcalfe S 

PROVIDER: S-EPMC10533225 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature