Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner.

ABSTRACT: Aging is associated with exacerbated systemic inflammation (inflammaging) and the progressive loss of immune system function (immunosenescence). Leukocyte migration is necessary for effective immunity; however, dysregulated trafficking of leukocytes into tissue contributes to inflammaging and the development of age-related inflammatory diseases. Aging modulates leukocyte trafficking under inflammatory conditions; however, whether aging modulates leukocyte trafficking under homeostatic conditions remains to be elucidated. Although immune responses are evidently sexually dimorphic, limited studies have investigated the effect of sex on age-related changes to leukocyte trafficking processes. Here, we investigated age-related and sex-specific changes to the leukocyte populations within the per

SUBMITTER: Hopkin SJ 

PROVIDER: S-EPMC10533226 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature