Allelic compatibility in plant immune receptors facilitates engineering of new effector recognition specificities.

ABSTRACT: Engineering the plant immune system offers genetic solutions to mitigate crop diseases caused by diverse agriculturally significant pathogens and pests. Modification of intracellular plant immune receptors of the nucleotide-binding leucine-rich repeat (NLR) receptor superfamily for expanded recognition of pathogen virulence proteins (effectors) is a promising approach for engineering disease resistance. However, engineering can cause NLR autoactivation, resulting in constitutive defense responses that are deleterious to the plant. This may be due to plant NLRs associating in highly complex signaling networks that coevolve together, and changes through breeding or genetic modification can generate incompatible combinations, resulting in autoimmune phenotypes. The sensor and helper NLRs of t

SUBMITTER: Bentham AR 

PROVIDER: S-EPMC10533329 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature