Spatial predictors of immunotherapy response in triple-negative breast cancer.

ABSTRACT: Immune checkpoint blockade (ICB) benefits some patients with triple-negative breast cancer, but what distinguishes responders from non-responders is unclear¹. Because ICB targets cell-cell interactions², we investigated the impact of multicellular spatial organization on response, and explored how ICB remodels the tumour microenvironment. We show that cell phenotype, activation state and spatial location are intimately linked, influence ICB effect and differ in sensitive versus resistant tumours early on-treatment. We used imaging mass cytometry³ to profile the in situ expression of 43 proteins in tumours from patients in a randomized trial of neoadjuvant ICB, sampled at three timepoints (baseline, n = 243; early on-treatment, n = 207; post-treatment, n = 2

SUBMITTER: Wang XQ 

PROVIDER: S-EPMC10533410 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature