Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes.

ABSTRACT: Genome-wide association studies have identified numerous loci with allelic associations to Type 1 Diabetes (T1D) risk. Most disease-associated variants are enriched in regulatory sequences active in lymphoid cell types, suggesting that lymphocyte gene expression is altered in T1D. Here we assay gene expression between T1D cases and healthy controls in two autoimmunity-relevant lymphocyte cell types, memory CD4⁺/CD25⁺ regulatory T cells (Treg) and memory CD4⁺/CD25^- T cells, using a splicing event-based approach to characterize tissue-specific transcriptomes. Limited differences in isoform usage between T1D cases and controls are observed in memory CD4⁺/CD25^- T-cells. In Tregs, 402 genes demonstrate differences in isoform usag

SUBMITTER: Newman JRB 

PROVIDER: S-EPMC10533491 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature