Assessing robustness of quantitative susceptibility-based MRI radiomic features in patients with multiple sclerosis.

ABSTRACT: Multiple Sclerosis (MS) is an autoimmune demyelinating disease characterised by changes in iron and myelin content. These biomarkers are detectable by Quantitative Susceptibility Mapping (QSM), an advanced Magnetic Resonance Imaging technique detecting magnetic properties. When analysed with radiomic techniques that exploit its intrinsic quantitative nature, QSM may furnish biomarkers to facilitate early diagnosis of MS and timely assessment of progression. In this work, we explore the robustness of QSM radiomic features by varying the number of grey levels (GLs) and echo times (TEs), in a sample of healthy controls and patients with MS. We analysed the white matter in total and within six clinically relevant tracts, including the cortico-spinal tract and the optic radiation. After optimis

SUBMITTER: Fiscone C 

PROVIDER: S-EPMC10533494 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature