Galectin-9 interacts with Vamp-3 to regulate cytokine secretion in dendritic cells.

ABSTRACT: Intracellular vesicle transport is essential for cellular homeostasis and is partially mediated by SNARE proteins. Endosomal trafficking to the plasma membrane ensures cytokine secretion in dendritic cells (DCs) and the initiation of immune responses. Despite its critical importance, the specific molecular components that regulate DC cytokine secretion are poorly characterised. Galectin-9, a ß-galactoside-binding protein, has emerged as a novel cellular modulator although its exact intracellular roles in regulating (immune) cell homeostasis and vesicle transport are virtually unknown. We investigated galectin-9 function in primary human DCs and report that galectin-9 is essential for intracellular cytokine trafficking to the cell surface. Galectin-9-depleted DCs accumulate cytokine-contain

SUBMITTER: Santalla Mendez R 

PROVIDER: S-EPMC10533640 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature