Longitudinal observational study protocol - Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO).

ABSTRACT:

Introduction

Very preterm infants are at risk of abnormal microbiome colonisation in the first weeks to months of life. Several important associated factors have been identified including gestational age, mode of delivery, antibiotic exposure and feeding. Preterm infants are at risk of a number of pathologies for which the microbiome may play a central role, including necrotising enterocolitis and sepsis. The objective of this study is to determine detailed microbiome changes that occur around implementation of different management practices including empiric antibiotic use, advancement of feeds and administration of probiotics during admission to the neonatal intensive care unit.

Methods and analysis

A single-site, longitudinal observational study of infants born less than

SUBMITTER: Healy D 

PROVIDER: S-EPMC10533688 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature