Multi-breed host rumen epithelium transcriptome and microbiome associations and their relationship with beef cattle feed efficiency.

ABSTRACT: Understanding host-microbial interactions in the rumen and its influence on desirable production traits may lead to potential microbiota manipulation or genetic selection for improved cattle feed efficiency. This study investigated the host transcriptome and its correlation with the rumen archaea and bacteria differential abundance of two pure beef cattle breeds (Angus and Charolais) and one composite beef hybrid (Kinsella) divergent for residual feed intake (RFI; low-RFI vs. high-RFI). Using RNA-Sequencing of rumen tissue and 16S rRNA gene amplicon sequencing, differentially expressed genes (FDR ≤ 0.05, |log₂(Fold-change) >|2) and differentially abundant (p-value < 0.05) archaea and bacteria amplicon sequence variants (ASV) were determined. Significant correlations between gene

SUBMITTER: Fonseca PAS 

PROVIDER: S-EPMC10533831 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature