Retina-derived signals control pace of neurogenesis in visual brain areas but not circuit assembly.

ABSTRACT: Brain development is orchestrated by both innate and experience-dependent mechanisms, but their relative contributions are difficult to disentangle. Here we asked if and how central visual areas are altered in a vertebrate brain depleted of any and all signals from retinal ganglion cells throughout development. We transcriptionally profiled neurons in pretectum, thalamus and other retinorecipient areas of larval zebrafish and searched for changes in lakritz mutants that lack all retinal connections. Although individual genes are dysregulated, the complete set of 77 neuronal types develops in apparently normal proportions, at normal locations, and along normal differentiation trajectories. Strikingly, the cell-cycle exits of proliferating progenitors in these areas are delayed, and a greate

SUBMITTER: Sherman S 

PROVIDER: S-EPMC10533834 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature