Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex.

ABSTRACT: Abnormalities in neocortical and synaptic development are linked to neurodevelopmental disorders. However, the molecular and cellular mechanisms governing initial synapse formation in the prenatal neocortex remain poorly understood. Using polysome profiling coupled with snRNAseq on human cortical samples at various fetal phases, we identify human mRNAs, including those encoding synaptic proteins, with finely controlled translation in distinct cell populations of developing frontal neocortices. Examination of murine and human neocortex reveals that the RNA binding protein and translational regulator, CELF4, is expressed in compartments enriched in initial synaptogenesis: the marginal zone and the subplate. We also find that Celf4/CELF4-target mRNAs are encoded by risk genes for adverse neur

SUBMITTER: Salamon I 

PROVIDER: S-EPMC10533865 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature