Expanding mammography screening for women aged 40-80 years: evidence from a modeling approach using real-world data.

ABSTRACT: If a mammography screening program (MS) is to be expanded, the benefit must be demonstrated for each additional age cohort. For the age interval between 40 and 80 years, the association between tumor-related and tumor-independent mortality of 21 2-year cohorts is modeled using up-to-date, valid data to determine MS outcome. Disease trajectories with and without biennial MS are extrapolated for each age cohort using the available data and knowledge on MS. The competing mortality is randomly generated for each age cohort with and without MS for a follow-up period of 20 years. Analyses of the modeled cohorts describe incremental change for each year, quantifying the changing benefits of MS. With increasing age, the proportion of tumor-independent mortality before and with metastatic disease i

SUBMITTER: Holzel D 

PROVIDER: S-EPMC10533880 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature