Risk relationship between leukocyte telomere length and constipation: a Mendelian randomization study.

ABSTRACT:

Objective

Some epidemiological studies have investigated the associations between aging and constipation, yet their outcomes are inconclusive, so we strive to ascertain whether aging is the cause of constipation.

Methods

We conducted a two-sample Mendelian randomization (MR) analysis using publicly accessible genome-wide association study (GWAS) summary statistics. As a marker of cellular and biological aging, we employed 15 single-nucleotide polymorphisms as instrumental variables for leukocyte telomere length (LTL) as exposure and a GWAS for constipation in the Finnish database as an outcome. To select the instrumental variables strongly associated with the phenotype, we eliminated confounding factors and direct effects outcomes to determine the causal relationship of expo

SUBMITTER: Chi Z 

PROVIDER: S-EPMC10533926 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature