Effects of dexmedetomidine in non-operating room anesthesia in adults: a systematic review with meta-analysis.

ABSTRACT:

Background

Dexmedetomidine (DEX) is an α2-adrenergic receptor agonist used for its sedative, analgesic, and anxiolytic effects. Non-Operating Room Anesthesia (NORA) is a modality of anesthesia that can be done under general anesthesia or procedural sedation or/and analgesia. In this particular setting, a level-2 sedation, such as the one provided by DEX, is beneficial. We aimed to study the effects and safety of DEX in the different NORA settings in the adult population.

Methods

A systematic review with meta-analysis of randomized controlled trials was conducted. Interventions using DEX only or DEX associated with other sedative agents, in adults (18 years old or more), were included. Procedures outside the NORA setting and/or without a control group without DEX were exclude

SUBMITTER: Fonseca FJ 

PROVIDER: S-EPMC10533981 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature