Tumorigenic effects of human mesenchymal stromal cells and fibroblasts on bladder cancer cells.

ABSTRACT:

Background

Patients with muscle-invasive bladder cancer face a poor prognosis due to rapid disease progression and chemoresistance. Thus, there is an urgent need for a new therapeutic treatment. The tumor microenvironment (TME) has crucial roles in tumor development, growth, progression, and therapy resistance. TME cells may also survive standard treatment of care and fire up disease recurrence. However, whether specific TME components have tumor-promoting or tumor-inhibitory properties depends on cell type and cancer entity. Thus, a deeper understanding of the interaction mechanisms between the TME and cancer cells is needed to develop new cancer treatment approaches that overcome therapy resistance. Little is known about the function and interaction between mesenchymal stromal ce

SUBMITTER: Frerichs LM 

PROVIDER: S-EPMC10534007 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature