Extracellular thiamine concentration influences thermogenic competency of differentiating neck area-derived human adipocytes.

ABSTRACT:

Introduction

Brown adipose tissue (BAT) dissipates energy in the form of heat majorly via the mitochondrial uncoupling protein 1 (UCP1). The activation of BAT, which is enriched in the neck area and contains brown and beige adipocytes in humans, was considered as a potential therapeutic target to treat obesity. Therefore, finding novel agents that can stimulate the differentiation and recruitment of brown or beige thermogenic adipocytes are important subjects for investigation. The current study investigated how the availability of extracellular thiamine (vitamin B1), an essential cofactor of mitochondrial enzyme complexes that catalyze key steps in the catabolism of nutrients, affects the expression of thermogenic marker genes and proteins and subsequent functional parameters duri

SUBMITTER: Vinnai BA 

PROVIDER: S-EPMC10534038 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature