Early infancy dysbiosis in food protein-induced enterocolitis syndrome: A prospective cohort study.

ABSTRACT:

Background

The microbiome associations of food protein-induced enterocolitis syndrome (FPIES) are understudied. We sought to prospectively define the clinical features of FPIES in a birth cohort, and investigate for the evidence of gut dysbiosis.

Methods

We identified children diagnosed with FPIES in the Gastrointestinal Microbiome and Allergic Proctocolitis Study, a healthy infant cohort. Children were assessed and stools were collected at each well child visit. The clinical features of the children with FPIES were summarized. Stool microbiome was analyzed using 16S rRNA sequencing comparing children with and without FPIES.

Results

Of the 874 children followed up for 3 years, 8 FPIES cases (4 male) were identified, yielding a cumulative incidence of 0.92%. The most c

SUBMITTER: Su KW 

PROVIDER: S-EPMC10534226 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature