Prognosis of limb‑salvage treatment of osteosarcoma in adolescent patients: a meta‑analysis.

ABSTRACT: To evaluate the effectiveness of limb-salvage treatment for osteosarcoma in adolescent patients, a comprehensive search on PubMed, Embase and Cochrane Library was conducted. Studies with a clear diagnosis of osteosarcoma were included and duplicate publications, studies without full text or incomplete information, those with an inability to extract data, divergent definitions of exposure, animal experiments, reviews, and systematic reviews were excluded. The data were analyzed using STATA 15.1. The findings of the present study revealed that overall survival (OS) and progression-free survival (PFS) of patients with osteosarcoma in the limb-salvage treatment group were significantly longer than those in the amputation treatment group [hazard ratio (HR)=0.71; 95% confidence interval (CI): 0.

SUBMITTER: Wang L 

PROVIDER: S-EPMC10534281 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature